Respiratory
Chronic respiratory diseases are long-term illnesses that affect the lungs and airways and impair a person’s ability to breathe. Common chronic respiratory diseases include asthma and chronic obstructive pulmonary disease (COPD). The rising prevalence of individuals affected by chronic respiratory diseases continues to be a global health challenge, requiring focused clinical research and specialized expertise to bring new therapies to market.
Dr. Vince Clinical Research (DVCR) offers broad experience in respiratory trials, led by board-certified pulmonologist Dr. Steven Hull, a pulmonary and critical care physician with more than 35 years of experience. Multiple senior team members supporting these studies also bring significant experience in asthma, allergy and other respiratory conditions. This collective expertise ensures DVCR delivers high-quality respiratory data across all phases of research.
Capabilities
Dr. Vince Clinical Research provides a full-service solution customized to fit the needs of your respiratory clinical trial. Our physician-led Phase I clinical pharmacology unit is equipped with 90 beds for overnight trials, including 8 private research suites for individual domiciling. The phase I unit offers luxurious amenities to support recruitment and retention and can enroll subject populations across a wide range of respiratory-related indications.
We conduct the following studies in both healthy volunteers and patient populations at our Phase 1 unit and our global network of strategic site partners:
- First-in-Human (FIH):
- KSingle Ascending Dose (SAD) which may include:
- [Early QT/cardiac safety in partnership with Clario
- [Food Effect cohort
- KMultiple Ascending Dose (MAD) which may include:
- [Patient cohorts
- KCombined SAD/MAD which may include:
- [Patient cohorts
- NDA-enabling clinical pharmacology studies:
- KDrug-Drug Interaction
- KThorough QT/QTc in partnership with Clario
- KFood Effect
- KBioavailability/Bioequivalence
- KPharmacokinetic/Pharmacodynamic
- Phase Ib/IIa Proof-of-Concept (POC)
- Phase II multi-site patient trials
DVCR’s clinical team possess decades of experience conducting assessments, procedures and questionnaires specific to respiratory studies, including but not limited to:
- Spirometry
- Pulse Oximetry
- Capnography
- Arterial Blood Gases
Click below to receive more information on how our CRO can support your upcoming respiratory trial.
Indications
DVCR’s clinical staff and strategic multi-site network are experienced in Phase I-III clinical studies for the following indications:
- Asthma
- Chronic Obstructive Pulmonary Disease (COPD)
- Pulmonary Hypertension
- Idiopathic Pulmonary Fibrosis
- Chronic Cough
Meet Our Experts
DVCR has assembled an industry-leading team of experts to oversee the design, planning and conduct of respiratory trials at our world-class phase 1 clinical pharmacology unit and our strategic partner sites. The following members of our company are heavily involved in the oversight, planning, and day-to-day conduct of your clinical studies:
Steven Hull, MD, FCCP, FAASM
Medical Director & Principal Investigator
Bio
Dr. Steven Hull serves as Medical Director and a Principal Investigator at DVCR. He is a seasoned researcher, having participated in more than 550 clinical trials as an Investigator or Medical Monitor. He has over 30 years of clinical experience in Pulmonary, Critical Care, and Sleep Medicine. Dr. Hull takes pride in his hands-on approach and collegiality, which provides DVCR with the medical expertise and guidance to enhance the performance, quality and oversight of the investigators and research team.
William J. Lavery, MD, PhD
Principal Investigator
Bio
Dr. William Lavery serves as a Principal Investigator at DVCR. He has participated in over 50 clinical trials as a Principal Investigator or Sub-Investigator and is board-certified by the American Board of Allergy and Immunology. In his journey to become a Physician Scientist, Dr. Lavery earned a PhD in Molecular and Cellular Physiology. Dr. Lavery has published over a dozen peer-reviewed research articles and book chapters as well as presented at numerous national meetings. Prior to joining DVCR, he worked in private practice treating adult and pediatric patients for various allergy, asthma and immunologic disorders.
Michelle Neaderhiser
Director, Study Management
Bio
Michelle Neaderhiser is a registered nurse with over 25 years of clinical research experience. Her expertise is in the management of Clinical Operations and Study Management for Phase 1 clinical trials. She focuses on completing comprehensive protocol reviews as they relate to operationalizing trials for clinical conduct. She is known for collaboratively working with multiple departments to effectively conduct trials from study start-up through final report. She prides herself on prioritizing client requests and providing excellent customer service.
Lora Adriano
Senior Study Manager
Meet Our Experts
DVCR has assembled an industry-leading team of experts to oversee the design, planning and conduct of respiratory trials at our world-class phase 1 clinical pharmacology unit and our strategic partner sites. The following members of our company are heavily involved in the oversight, planning, and day-to-day conduct of your clinical studies:
Steven Hull, MD, FCCP, FAASM
Medical Director & Principal Investigator
Bio
Dr. Steven Hull serves as Medical Director and a Principal Investigator at DVCR. He is a seasoned researcher, having participated in more than 550 clinical trials as an Investigator or Medical Monitor. He has over 30 years of clinical experience in Pulmonary, Critical Care, and Sleep Medicine. Dr. Hull takes pride in his hands-on approach and collegiality, which provides DVCR with the medical expertise and guidance to enhance the performance, quality and oversight of the investigators and research team.
William J. Lavery, MD, PhD
Principal Investigator
Bio
Dr. William Lavery serves as a Principal Investigator at DVCR. He has participated in over 50 clinical trials as a Principal Investigator or Sub-Investigator and is board-certified by the American Board of Allergy and Immunology. In his journey to become a Physician Scientist, Dr. Lavery earned a PhD in Molecular and Cellular Physiology. Dr. Lavery has published over a dozen peer-reviewed research articles and book chapters as well as presented at numerous national meetings. Prior to joining DVCR, he worked in private practice treating adult and pediatric patients for various allergy, asthma and immunologic disorders.
Michelle Neaderhiser
Director, Study Management
Bio
Michelle Neaderhiser is a registered nurse with over 25 years of clinical research experience. Her expertise is in the management of Clinical Operations and Study Management for Phase 1 clinical trials. She focuses on completing comprehensive protocol reviews as they relate to operationalizing trials for clinical conduct. She is known for collaboratively working with multiple departments to effectively conduct trials from study start-up through final report. She prides herself on prioritizing client requests and providing excellent customer service.
Lora Adriano
Senior Study Manager
Meet Our Experts
DVCR has assembled an industry-leading team of experts to oversee the design, planning and conduct of respiratory trials at our world-class phase 1 clinical pharmacology unit and our strategic partner sites. The following members of our company are heavily involved in the oversight, planning, and day-to-day conduct of your clinical studies:
Steven Hull, MD, FCCP, FAASM
Medical Director & Principal Investigator
Bio
Dr. Steven Hull serves as Medical Director and a Principal Investigator at DVCR. He is a seasoned researcher, having participated in more than 550 clinical trials as an Investigator or Medical Monitor. He has over 30 years of clinical experience in Pulmonary, Critical Care, and Sleep Medicine. Dr. Hull takes pride in his hands-on approach and collegiality, which provides DVCR with the medical expertise and guidance to enhance the performance, quality and oversight of the investigators and research team.
William J. Lavery, MD, PhD
Principal Investigator
Bio
Dr. William Lavery serves as a Principal Investigator at DVCR. He has participated in over 50 clinical trials as a Principal Investigator or Sub-Investigator and is board-certified by the American Board of Allergy and Immunology. In his journey to become a Physician Scientist, Dr. Lavery earned a PhD in Molecular and Cellular Physiology. Dr. Lavery has published over a dozen peer-reviewed research articles and book chapters as well as presented at numerous national meetings. Prior to joining DVCR, he worked in private practice treating adult and pediatric patients for various allergy, asthma and immunologic disorders.
Michelle Neaderhiser
Director, Study Management
Bio
Michelle Neaderhiser is a registered nurse with over 25 years of clinical research experience. Her expertise is in the management of Clinical Operations and Study Management for Phase 1 clinical trials. She focuses on completing comprehensive protocol reviews as they relate to operationalizing trials for clinical conduct. She is known for collaboratively working with multiple departments to effectively conduct trials from study start-up through final report. She prides herself on prioritizing client requests and providing excellent customer service.
Lora Adriano
Senior Study Manager
